The Singapore Airlines-backed carrier said the new service will be able to carry more than 100,000 passengers a year between the Philippines' capital of Manila and Macau.
"This link between Macau and Manila is a significant milestone for our airline as we gear up to our next phase of expansion," Tiger Airways chief executive officer Tony Davis said.
The airline said it expects demand to come from the many Filipino workers based in Macau and nearby Hong Kong, as well as tourists. Prices for the new service have not been announced.
Tiger Airways, 49 pct-owned by Singapore Airlines, is one of three low-cost carriers based in the city-state.
It currently flies from Singapore to Indonesia, Macau, the Philippines, Thailand and Vietnam.