The new arrangement has been facilitated through a new code-sharing agreement between the Mumbai-registered company and Belgium's Brussels Airlines.
The code-sharing deal will be signed by Jet Airways president Naresh Goyal and Brussels Airline chief Philippe Vander Putten in the Belgian capital on May 2 at a ceremony to be attended by by Belgian Prime Minister Guy Verhofstadt.
The formal announcement of the hubbing arrangement will be made at the same time.
The moves will allow Jet Airways to spread its wings across Europe, where currently it only flies to London's Heathrow, and also into the US and Canada.
"The hub will allow us to offer a more efficient, high-quality service linking India with Europe, the United States and Canada," the company said in a statement.